Crinagen's Formula is very similar to the well-known Revivogen Natural Scalp Therapy, and it comes at a very competitive price.
The new and improved Crinagen now contains 5% azelaic acid and Proanthocyanidins from grape seed extract for maximum potency. The only one of its kind topical lotion for hair loss prepared in accordance to the clinical study reported in the British Journal of Dermatology - up to 98% reduction in DHT !!
Safe for both men and women.
The current version of Crinagen contains the following: Distilled water, Polysorbate 20, Gamma linolenic acid, Proanthocyanidins (procyanidin oligomers from grape seed extract), Azelaic acid, Zinc acetate hydrate, Niacin, Vitamin B6 (as Pyridoxal-5-phosphate), Saw palmetto extract, Ginkgo biloba, Alpha linolenic acid, Oleic acid, Linoleic acid, Arachidonic acid, Palmitoleic acid, Tea tree oil, Witch hazel extract, Epilobium augustifolium, Epilobium parviflorum, Riboflavin, Vitamin E (as d-alpha tocopherol).
The key ingredients in Crinagen are:
(pronounced az-uh-LAY-ic) is a simple molecule ( HOOC(CH2)7COOH, CAS Number 123-99-9, also known as 1,9-Nonanedioic acid) that is found in some whole grains and in trace amounts in human bodies. Although it is an acid, it is an extremely weak acid - much weaker than vinegar. It's current use in medicine is in Azelex, which is a cream base containing azelaic acid as 20% of its weight. Azelex is available by prescription in the USA and is used in the treatment of acne.
Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it and zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor. The enzyme 5-AR (both types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to male prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles. The abstract of that article is further down this page.
We have not seen research that directly links the use of topical azelaic acid (or azelaic acid with zinc and B6) with hair growth. We feel that there is sufficient literature backing (in the Stamatiadis study and others) to include it in a Crinagen preparation.
In recent published research, Takahashi et al examined 1,000 different plant products to determine if any of them could influence hair growth. They determined that proanthocyanidins extracted from grape seeds promoted the prolieferation of hair cells by 230%. They also determined that proanthocyanidins converted the telogen (non-growing) phase of hair growth into the anagen (growing) phase of hair growth. In this experiement, proanthocyanidins displayed hair-cycle-converting activity which was similar to that of minoxidil. At the end of their report, the authors say that "WE are now investigating the possibility of the use of proanthocyanidins as agents for curing androgenic alopecia."
Zinc and Saw palmetto:
These are two of the most powerful ingredients of CrinagenTM are . Both agents have been shown to block the conversion of male sex hormones (such as testosterone) into dihydrotestosterone. Dihydrotestosterone is a potent hormone. Most researchers believe it is responsible for male-pattern hair loss. The ingredients in CrinagenTM accomplish this by blocking the enzyme 5 alpha-reductase, which is required to produce dihydrotestosterone. Since the ingredients contained in CrinagenTM are all natural ones, there are no hormonal side effects. The hallmark of male-pattern hair loss is the progressive miniaturization of hair follicles. This is caused by a genetic predisposition of individual hair follicles that renders them more sensitive to normal circulating levels of male sex hormones. This is because increased levels of 5 alpha-reductase in these follicles causes the conversion of male hormones (such as testosterone) into dihydrotestosterone. Dihydrotestosterone continues to damage and miniaturize hair follicles. As hair follicles are continually damaged by the ongoing effects of dihydrotestosterone, the body responds to this injury with an inflammatory response which is primarily mediated by the immune system. The cells of the immune system cause inflammatory reactions which further damage these hair follicles and eventually destroy them.
Procyanidin Oligomers:(also known as Proanthocyanidin) are naturally derived ingredients that have shown to stimulate hair growth similarly to Minoxidil (Rogaine®). Recent studies by Japanese scientists have shown that Procyanidin Oligomers possess growth stimulation activity toward hair epithelial cells in vitro and stimulate anagen induction in hair follicles in vivo. Addition of Procyanidin Oligomers to Revivogen is intended to increase the hair growth stimulation properties of the formula.
Directions for use:
Shake well before use. Apply 2-4 ml of the solution to the affected and surrounding areas of the scalp once daily. Gently massage the solution into the scalp for 10-20 seconds. Do not wash or rinse hair for at least three hours. For best results continue use on a daily basis. Store in a cool and dry place. Keep tightly closed. Results may vary.
Distilled water, Polysorbate 20, Gamma linolenic acid, Proanthocyanidins (procyanidin oligomers from grape seed extract), Azelaic acid, Zinc acetate hydrate, Niacin, Vitamin B6 (as Pyridoxal-5-phosphate), Saw palmetto extract, Ginkgo biloba, Alpha linolenic acid, Oleic acid, Linoleic acid, Arachidonic acid, Palmitoleic acid, Tea tree oil, Witch hazel extract, Epilobium augustifolium, Epilobium parviflorum, Riboflavin, Vitamin E (as d-alpha tocopherol).